2. Pharmacology (PHA) MCQ Questions | Frcamcq

Overview

Overview

Module 1 – General Pharmacology (Foundation)

Pharmacokinetics

Drug absorption
Bioavailability
Distribution
Protein binding
Volume of distribution
Redistribution
Metabolism
Hepatic extraction
First-pass metabolism
Elimination
Clearance
Half-life
Context-sensitive half-time
Multi-compartment models

Pharmacodynamics

Drug receptors
Agonists
Partial agonists
Inverse agonists
Competitive antagonists
Non-competitive antagonists
Dose-response curves
Potency
Efficacy
Therapeutic index
Therapeutic window
Drug interactions
Tolerance
Tachyphylaxis

Pharmacogenetics

Genetic variability
Enzyme polymorphisms
CYP450 system
Atypical plasma cholinesterase

Module 2 – Intravenous Anaesthetic Drugs

Study:

Propofol
Thiopental
Etomidate
Ketamine
Midazolam
Dexmedetomidine

For each drug know:

Chemistry
Preparation
Mechanism
PK
PD
Organ effects
Clinical uses
Contraindications
Toxicity

Module 3 – Inhalational Anaesthetic Agents

Study:

Sevoflurane
Isoflurane
Desflurane
Nitrous oxide

Topics

MAC
Factors affecting MAC
Uptake and distribution
Blood:gas partition coefficient
Vapor pressure
Organ effects
Metabolism
Environmental impact

Module 4 – Opioids

Study:

Morphine
Fentanyl
Alfentanil
Remifentanil
Oxycodone
Tramadol
Codeine

Know:

Receptors
PK/PD
Active metabolites
Side effects
Respiratory depression
Naloxone

Module 5 – Neuromuscular Blocking Drugs

Depolarising

Suxamethonium

Non-depolarising

Rocuronium
Vecuronium
Atracurium
Cisatracurium

Reversal

Neostigmine
Sugammadex

Topics

NMJ physiology
Fade
Monitoring
TOF
PTC

Module 6 – Local Anaesthetics

Study

Lidocaine
Bupivacaine
Levobupivacaine
Ropivacaine
Prilocaine

Topics

Chemistry
pKa
Lipid solubility
Protein binding
Differential block
LAST
Lipid rescue

Module 7 – Cardiovascular Drugs

Study

Vasopressors
Inotropes
Vasodilators
Beta blockers
Calcium channel blockers
Antiarrhythmics
ACE inhibitors
ARBs
Diuretics

Module 8 – Respiratory Drugs

β₂ agonists
Antimuscarinics
Steroids
Magnesium
Theophylline
Leukotriene antagonists

Module 9 – CNS Drugs

Anticonvulsants
Antidepressants
Antipsychotics
Parkinson drugs
Antiemetics
Sedatives

Module 10 – Endocrine Drugs

Insulin
Oral hypoglycaemics
Corticosteroids
Thyroid drugs
Oxytocin
Vasopressin

Module 11 – Fluids & Electrolytes

Crystalloids
Colloids
Blood products
Hypertonic saline
Albumin

Module 12 – Antimicrobials

Basic principles

Antibiotics
Antifungals
Antivirals

Module 13 – Toxicology

Local anaesthetic toxicity
Opioid overdose
Paracetamol
Salicylates
Organophosphates
Cyanide
Carbon monoxide

Module 14 – Special Pharmacology

Pregnancy
Paediatrics
Elderly
Renal failure
Liver disease

2. Pharmacology (PHA) MCQ Questions | Frcamcq